Pages: 102-108

Hepatoprotective activity of Plumbago zeylanica linn. against carbon tetrachloride-induced hepatotoxicity in rats

Author: I A Tayubi, A Desai, I H Madar, and H Al Ssadh

Category: Biology

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Abstract:

This paper evaluates the hepatoprotective activity of Plumbago zeylanica rhizome extracts against carbon tetrachloride (CCl4)-induced hepatotoxicity. Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of CCl4 (0.1 ml/kg/day for 10 days). Extracts of P. zeylanica rhizome were administered to the experimental rats (25 mg/kg/day, p.o. for 14 days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters (Protein, Cholesterol, Bilirubin, Alanine amino transaminase, and Aspartate amino transaminase activities). In rhizome extract-treated animals, the toxic effect of CCl4 was controlled significantly by restoration of the levels of Protein, Cholesterol, Bilirubin Alanine amino transaminase and Aspartate amino transaminase as compared to the control cohort, which evidenced the hepatoprotective activity. Rhizome extract of P. zeylanica possesses significant hepatoprotective activity.

Keywords: Hepatotoxicity, carbon tetrachloride, rhizome extract, plumbagin


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